I think Matt Yglesias is right that the small number of Republicans who were able to cast their vote in favor of confirming Kathleen Sebelius for Health & Human Services does not bode well for the chances of getting cooperation from Republicans on healthcare reform.
In theory this would be a good time to take our newly-formed SUPERMAJORITY and use it to pass good legislation that includes a public plan and tell Republicans to deal with it. Somehow I doubt that will be what will happen.